麻豆高清

- 靹戈硠 斓滌磮 "鞛犽摖 雵� 鞁犼步靹疙彫臧� 旯�鞏措倶氅� 鞛愴彁歃濍弰 旃橂�� 臧�電�"
- 靹戈硠鞝� 鞝曥嫚鞚橅暀 頃欖垹歆� Molecular Psychiatry(IF=11.8, JCR 靸侅渼 2.3%) 8鞗� 30鞚� 瓴岇灛

鈻� 鞕检�诫秬韯� 旯�膦呿晞 頇旐暀瓿� 甑愳垬, 臁半硲甑� 鞐瓣惮甑愳垬 

霃欔淡雽赌顷欔祼(齑濎灔 鞙れ灛鞗�)電� 氤戈祼 頇旐暀瓿� 旯�膦呿晞 甑愳垬 鞐瓣惮韺�(旯�膦呿晞(甑愳嫚鞝�鞛�, 霃欔淡雽赌顷欔祼 甑愳垬), 臁半硲甑�(鞝�1鞝�鞛�, 霃欔淡雽赌顷欔祼 鞐瓣惮甑愳垬))鞚� 靹戈硠 斓滌磮搿� ‘雵� 靻� 頊挫��旮� 鞁犼步欷勱赴靹疙彫(quiescent neural stem cells, 鞚错晿 qNSCs)臧� 鞛愴彁鞀ろ帣韸鸽熂鞛レ暊 氚滊硲鞐愳劀 氚滊硲鞚� 甏�氍� 鞐�頃犾潉 頃滊嫟’電� 旮办爠鞚� 氚濏瀳瓿�, 鞚措ゼ 鞝滌柎頃�鞙茧�滌崹 鞛愴彁歃濎潣 旃橂�� 臧�電レ劚鞚� 靸堧…瓴� 鞝滌嫓頄堧嫟瓿� 氚濏様雼�.

鞚措矆 鞐瓣惮 瓴瓣臣電� "Aberrant Neural Stem Cell Quiescence is the Gateway to Autism Development linked to Arid1b"霛茧姅 鞝滊�╈溂搿� 靹戈硠鞝� 鞝曥嫚鞚橅暀 頃欖垹歆�鞚� ‘攵勳瀽 鞝曥嫚鞚橅暀(Molecular Psychiatry, IF = 11.8, JCR 靸侅渼 2.3%)’鞐� 瓴岇灛霅橃柎 攴� 頃欖垹鞝� 鞖办垬靹膘潉 鞚胳爼氚涭晿雼�.

鞛愴彁歃濎溂搿滊弰 鞛� 鞎岆牑歆� 鞛愴彁鞀ろ帣韸鸽熂鞛レ暊(ASD)電� 頇橃瀽霌れ澊 鞝侅爤頃� 旃橂�岆ゼ 氚涭�� 氇豁暣 靷�須岇爜 瓿犽�疥臣 鞁�臧來暅 鞝侅潙 鞛レ暊 氍胳牅毳� 瓴�電� 靷�搿�臧� 斓滉芳 電橃柎雮橂姅 霌� 靷�須岇棎 毵夒寑頃� 鞓來枼鞚� 氙胳箻瓿� 鞛堧嫟. 鞛愴彁歃濎潃 氚滊硲 鞗愳澑鞚� 雼れ枒頃橁碃 歃濎儊 霕愴暅 毵れ毎 鞚挫�堨爜鞚搓赴 霑岆�胳棎, 欤茧�� 歃濎儊 鞕勴檾 欷戩嫭鞚� 頄夒彊旃橂�岇棎 鞚橃〈頃橂姅 霌� 歆堩櫂鞚� 攴茧掣 鞗愳澑鞚� 瓴�雰ロ暅 旃橂�� 鞝勲灥鞚� 歆�旮堦箤歆� 攵�臁表暅 鞁れ爼鞚挫棃雼�.

旯�膦呿晞 甑愳垬 鞐瓣惮韺�鞚� 靹戈硠 斓滌磮搿� qNSCs臧� 鞛愴彁歃� 氚滊硲鞚� ‘甏�氍�(gateway)’鞚挫瀽 歆堩櫂 氚滊硲鞚� ‘鞀れ渼旃�’ 鞐�頃犾潉 頃滊嫟電� 靷�鞁れ潉 攴滊獏頄堧嫟. 鞐瓣惮韺�鞚� 鞁犼步欷勱赴靹疙彫 韸轨澊鞝侅澑 Arid1b 臁瓣贝攵� 鞝滉卑(conditional knockout) 霃欕�茧��雿胳潉 鞚挫毄頃�, 鞛愴彁歃� 頇橃瀽鞚� 雵岇棎靹� 甏�彀半悩電� 牍勳爼靸侅爜 鞁犼步氚滊嫭 順勳儊鞚� 鞛愴彁歃� 鞙犽皽 鞗愳澑鞚胳�� 氚滊硲 瓴瓣臣搿� 雮橅儉雮橂姅 順勳儊鞚胳�� 毹检爛 攴滊獏頄堧嫟. 鞐瓣惮 瓴瓣臣, 鞛愴彁 鞙犽皽 鞙犾爠鞛愳澑 Arid1b毳� 鞁犼步欷勱赴靹疙彫鞐愳劀毵� 響滌爜鞙茧�� 鞝滉卑頄堨潉 霑� 鞛愴彁歃濎儊鞚� 霘滊牱頃橁矊 氚滍槃霅愳溂氅�, 鞚措姅 鞁犼步欷勱赴靹疙彫鞚� 牍勳爼靸侅爜 頄夒彊鞚� 鞛愴彁歃� 氚滊硲 鞗愳澑鞚� 霅� 靾� 鞛堧嫟電� 靷�鞁れ潉 靹戈硠 斓滌磮搿� 歃濍獏頃� 瓴冹澊雼�.

霕愴暅, 旯� 甑愳垬 鞐瓣惮韺�鞚� 鞛愴彁歃� 氇�雿� 毵堨毎鞀� 雵岇潣 鞁犼步欷勱赴靹疙彫毳� 雼�鞚检劯韽� 鞁滍��鞁� 氚╇矔鞙茧�� 攵勳劃頃�, qNSCs臧� 旯婌潃 頊挫��旮� 靸來儨(Deep quiescent state)搿� 鞝勴櫂霅橂┌ 頉勳劚鞙犾爠頃欖爜 響滌嫕鞚� H3K27me3臧� 牍勳爼靸侅爜鞙茧�� 於曥爜霅橂姅 順勳儊鞚� 氚滉铂頄堧嫟. 鞐瓣惮韺�鞚� 鞚� 順勳儊鞚� 鞙犾晞旮� 雵� 氚滊嫭 瓿检爼鞐愳劀 鞁犼步氚滌儩鞚� 鞁�臧來晿瓴� 鞝�頃错晿電� 霌� ‘鞛愴彁歃濎潣 頃奠嫭 氅旍护雼堨��’鞙茧�� 鞛戨彊頃滊嫟瓿� 氚濏様雼�.

韸鬼瀳 鞐瓣惮韺�鞚� 霃欕�茧��雿胳棎靹� 鞏奠牅鞝� GSK-126 靷�鞖� 鞁�, qNSCs鞐愳劀 H3K27me3臧� 牍勳爼靸侅爜鞙茧�� 於曥爜霅橂姅 順勳儊鞚� 鞏奠牅頃� 靾� 鞛堨潓鞚� 氤挫棳欷�雼�. 鞐瓣惮毳� 韱淀暣 靻愳儊霅� 鞁犼步氚滌儩鞚� 鞝曥儊 須岆车霅橂┌, 靷�須岇劚 瓴绊暔 氚� 靷�須岇爜 旮办柕霠� 鞝�頃� 霌� 鞛愴彁歃濎潣 雽�響� 歃濎儊旯岇�� 鞕勴檾霅� 靾� 鞛堨潓鞚� 鞁ろ棙鞝侅溂搿� 鞛呾�濏暣雰堧嫟.

鞚措矆 鞐瓣惮電� 鞛愴彁歃� 頇橃瀽 鞙犽灅 雵� 鞓り皜雲胳澊霌滌檧 鞁犼步欷勱赴靹疙彫鞐愳劀霃� 霃欖澕頃� 氤戨Μ 順勳儊 鞐�鞁� 瓴�歃濏枅雼�. 鞐瓣惮鞐� 霐半ゴ氅�, ARID1B 霃岇棸氤�鞚措ゼ 臧�歆� 頇橃瀽 鞙犽灅 雵� 鞓り皜雲胳澊霌滌檧 鞁れ牅 鞛愴彁歃� 頇橃瀽鞚� 鞁犼步欷勱赴靹疙彫鞐愳劀霃� qNSCs鞚� 旯婌潃 頊挫��旮� 靸來儨 鞝勴櫂鞚� 瓿淀喌鞝侅溂搿� 甏�彀半悙雼�. 鞚措姅 鞛愴彁歃� 氚滊硲 旮办爠鞚� 韸轨爼 靻岇晞旮半ゼ 雱橃柎 靹膘澑旮办棎霃� 霃欖澕頃橁矊 氚滉铂 臧�電ロ晿雼る姅 靷�鞁れ潉 靹戈硠 斓滌磮搿� 鞛呾�濏暅 瓴瓣臣雼�.

旯�膦呿晞 甑愳垬電� “鞚措矆 鞐瓣惮毳� 韱淀暣 鞛愴彁歃� 氚滊硲鞚� 鞗愳澑鞚� 雵� 靻� 頊挫��旮� 鞁犼步欷勱赴靹疙彫鞚� 牍勳爼靸侅爜 頇滌劚鞐� 鞛堨潓鞚� 氚滉铂頄堦碃, 鞚措煬頃� 靹疙彫臧� 鞛愴彁歃� 氚滊硲鞚� 頃奠嫭 鞗愳澑鞛勳潉 歃濍獏頄堧嫟”瓿� 氚濏瀳氅�, “靹膘澑旮办棎霃� 頊挫��旮� 鞁犼步欷勱赴靹疙彫鞚� 鞚挫儊鞚� 鞛愴彁歃濎潉 鞙犽皽頃� 靾� 鞛堧嫟電� 靷�鞁れ潃 鞛愴彁歃濎澊 雼�靾滍暅 氚滊嫭鞛レ暊毳� 雱橃柎 韽夓儩 甏�毽� 臧�電ロ暅 歆堩櫂鞛勳潉 鞁滌偓頃橂姅 欷戩殧頃� 氚滉铂”鞚措澕瓿� 臧曥“頄堧嫟.

頃滍幐, 鞐瓣惮韺�鞚� “旮办〈 旃橂�岆矔鞚� 頃滉硠毳� 雱橃柎, 鞛愴彁歃濎潣 攴茧掣鞝侅澑 鞗愳澑鞚� 頃搓舶頃橂姅 瓴冹澊 氇╉憸”霛茧┌, “頊挫��旮� 鞁犼步欷勱赴靹疙彫鞚� 臁办爤鞚� 韮�旯冹溂搿� 頃� 旃橂�岆矔鞚� 鞁れ牅 鞛勳儊鞐� 鞝侅毄霅� 靾� 鞛堧弰搿� 於旉皜 鞐瓣惮鞕� 鞛勳儊鞁滍棙鞚� 鞚挫柎臧� 瓿勴殟”鞚措澕瓿� 鞝勴枅雼�. 鞚措矆 鞐瓣惮電� 氩旊秬觳� 鞛�靸濎潣耄岅赴靾犼皽氚滌偓鞐呺嫧, 雽赌顷欖�戩爯鞐瓣惮靻� 歆�鞗愳偓鞐�, 鞚戈车鞎勳泊靹疙彫 旮半皹 鞛�靸濎潣耄岅赴靾犼皽氚� 瓿检牅鞚� 歆�鞗愳潉 氚涭晞 靾橅枆霅愲嫟.